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It’s Meryl & Hillary – BFFs!

Hillary and Bill Clinton pose for photos.

Hillary and Bill Clinton pose for photos. (AP)

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Hillary Rodham Clinton and Meryl Streep put on their brightest smiles to snap a self-portrait at the Kennedy Center Honors Gala dinner at the State Department.

Acting as hostess, Clinton worked the room at the star-studded Saturday-night fete, held for the 2012 Kennedy Center Honorees ahead of last night’s Honors Gala.

She even took time to pose for fans with her hubby, ex-President Bill Clinton (inset).

Among the honorees attending were members of Led Zeppelin, blues icon Buddy Guy, Dustin Hoffman and David Letterman.

At one point, the ex-prez had to be coaxed to pose for a photo with the honorees.

Streep, who won an Oscar playing Margaret Thatcher in “The Iron Lady,” is a professed fan of the secretary of state.

“She has turned out to be the voice of her generation. I’m an actress, and she is the real deal,” she said this year at the Women in the World Summit at Lincoln Center.

The Honors Gala will air on CBS Dec. 26.