They’re supposed to go to “hot spots” — not spread them.
Singles in Manhattan’s trendiest neighborhoods are more likely to contract the nasty, sore-producing, sexually transmitted disease syphilis, a new study claims.
Nightlife areas such as SoHo, Murray Hill and the Upper West Side are home to 10 times more syphilis-infected residents than the city’s average, according to the city Department of Health.
Roughly 125 people — taken from a sample of 100,000 — tested positive for the disease in those three neighborhoods.
But it’s not just the posh ZIP codes that make playing the field sound like playing with fire.
The Tremont section of The Bronx — where 43 percent of residents are below the federal poverty line — is home to the city’s highest STD rate, the study found.
In the report, which uses data from 2010, researchers also pinpoint areas with the highest rates of hepatitis B and C, chlamydia, gonorrhea and HIV.
The findings reveal:
* The Bronx is the borough where you’d least like to have a one-night stand. Roughly 68 percent of neighborhoods in the borough were found to have “high” rates of more than one STD.
* Staten Island is the healthiest place to hook up. Not a single neighborhood in the borough made the agency’s top-20 list for STDs.
* Thirteen out of 20 of the neighborhoods with the highest HIV and syphilis rates are in Manhattan.
* HIV and hepatitis C ran most rampant in gentrifying Bedford-Stuyvesant, Crown Heights, Williamsburg and Harlem.
* Neighborhoods with the highest rates of chlamydia and gonorrhea include the South Bronx, central Brooklyn and northern Manhattan.
* Health officials note TB and hepatitis B are most prevalent in the city’s immigrant communities. More than half of Queens’ worst-ranked neighborhoods are home to predominantly foreign-born residents.
Areas with the highest hepatitis rates — including Chelsea and Morningside Heights — rank 10 times the city’s average.
Additional reporting by Natalie O’Neill